Black/New Zealand White Mice Autoreactivity in Lupus-Prone New Zealand L Chain Allelic Inclusion Does Not Increase
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L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.
L chain allelic inclusion has been proposed as a B cell tolerance mechanism in addition to clonal deletion, clonal anergy, and receptor editing. It is said to rescue autoreactive B cells from elimination by diluting out the self-reactive BCR through the expression of a second innocuous L chain. In autoimmune animals, such as lupus-prone mice, allelically included B cells could be activated and ...
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تاریخ انتشار 2013